eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | li-fraumeni syndrome |
| Comorbidity | C0001418|adenocarcinoma |
| Sentences | 6 |
| PubMedID- 20936707 | Modeling prostate cancer in the mouse has shown that while pten deletion in prostate epithelial cells leads to adenocarcinoma, combined loss of pten and tp53 results in rapidly developing disease with greater tumor burden and early death. |
| PubMedID- 22737468 | Missense and nonsense mutations of p53 gene in patients with colorectal adenocarcinoma in isfahan, central iran. |
| PubMedID- 23168175 | Mutations of the tp53 gene in adenocarcinoma and squamous cell carcinoma of the cervix: a systematic review. |
| PubMedID- 25111876 | These properties have been assessed in vitro using 3 cell types: caco-2 cells (from a human colon adenocarcinoma) with a non-functional p53 gene. |
| PubMedID- 24169260 | Background: in lung adenocarcinoma, inactivation of the tumor suppressor p53 may abrogate a safeguard mechanism preventing the development of tumors with activating mutations in egfr or kras. |
| PubMedID- 25904052 | Of interest, an egfr deletion in exon 19 was observed in the well-differentiated adenocarcinoma, that was associated with a concomitant tp53 mutation (r248w) in the more de-differentiated area. |
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